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Presepsin is an immunologic biomarker which has been demonstrated as new, emerging, early indicator for the detection of different infections. The biological function of presepsin is not well known. However, it is believed that it may be a regulatory molecule of the adaptive immune system and also a stimulator of monocyte phagocytosis.


Presepsin is a soluble PRR. Presepsin in the circulation is an indicator of monocyte-macrophage activation in response to pathogens. Clinical relevance. Several clinical studies have demonstrated that presepsin is a specific and sensitive marker for the diagnosis, severity assessment and outcome prediction of sepsis.


Presepsin levels on PODs 3, 5, and 7 after gastrectomy is a more useful biomarker of postoperative infectious complications compared to CRP, WBCs, and Neuts, with a high sensitivity and specificity.
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PATHFAST® Presepsin è un test immunoenzimatico in chemiluminescenza per la misura quantitativa in vitro della concentrazione di Presepsina (sCD14-ST) nel sangue intero o nel plasma. PATHFAST® Presepsin viene utilizzato quale ausilio nella diagnosi e nella prognosi di sepsi, nella definizione del grado di severità della sepsi ed è un valido ...


3. Measurement of presepsin. An presepsin assay kit using antibody and a special sandwich technique is useful for qualitative and quantitative measurement of presepsin with appropriate sensitivity and specificity [31].Firstly, a traditional two-step sandwich enzyme-linked immunosorbent assay (ELISA) was used for the detection of presepsin by the recombinant CD14 (S286C) as standard within 4 h.


Presepsin concentrations on admission reflects the severity of sepsis. • Procalcitonin has no power for discriminating septic shock from sepsis. • Presepsin strongly correlates with SOFA score, as such it is the best among tested biomarkers, for describing multiple organ dysfunction/failure.


Presepsin, OPN, CCL2, suPAR, and TLR2 all decreased significantly with increasing time of recovery after surgery in PJI patients. Presepsin can be considered a useful tool for the diagnosis and clinical monitoring of PJI and can be backed by a panel of new inflammatory markers involved in monocyte-/macrophage-mediated inflammatory responses, such as OPN, CCL2, TLR2, and suPAR.